DOCTORS'
Medical Case Studies
DOCTORS'
Medical Case Studies
CPT-11
Irinotecan
Irinotecan is a drug used for the treatment of cancer. Irinotecan is a topoisomerase 1 inhibitor with IC50s of 15.8 and 5.17 μM for LoVo cells and HT-29 cells, respectively, which prevents DNA from unwinding. In chemical terms, it is a semisynthetic analogue of the natural alkaloid camptothecin. Its main use is in colon cancer, in particular, in combination with other chemotherapy agents. This includes the regimen FOLFIRI, which consists of infusional 5-fluorouracil, leucovorin, and irinotecan. Irinotecan received accelerated approval by the U...
CPT-11 - List of case studies
- Diffuse Intra-Axial expansive Lesion of the Enchephalic Trunk
-
include temozolomide, erlotonib+rapamycin, bevacizumab + CPT-11, and may other common regimens can also be considered. ... temozolomide, erlotonib, rapamycin, bevacizumab, CPT-11, steroid saving agents, celecoxib, bevacizumab. Treatments ...
- Glioblastoma
-
failed then could consider Carboplatin or BCNU or CPT-11 . - Would ... , CCNU , Carboplatin , BCNU , CPT-11 , AVASTIN , bevacizumab, Tarceva , rapamycin , ...
- Drugs
-
CDDP and 5-FU ci) CEVAIE CHOP COH CPT-11 Cafergot Calcitonin Calcium Calcium carbonate ...