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Temozolomide

Temozolomide
Temozolomide (brand names Temodar and Temodal Schering-Plough Corporation) is an oral alkylating agent which can be used for the treatment of Grade IV astrocytoma — an aggressive brain tumor, also known as glioblastoma multiforme as well as melanoma, a form of skin cancer. It is also indicated for Grade III Anaplastic Astrocytoma and not indicated for, but now used to treat oligodendroglioma brain tumors in some countries, replacing the older (and less well-tolerated) PCV regimen. The agent was developed by Malcolm Stevens and his team at Aston University in Birmingham, A derivative of imidazotetrazine, temozolomide is the prodrug of MTIC (3-methyl-imidazole-4-carboxamide)...
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Chemotherapy - List of case studies

spreading pancreatic cancer

disease progresses while on Octreotide LAR, a chemotherapy combination of platinum and etoposide would be ... Octreotide LAR (sandostatin), platinum and etoposide (chemotherapy combination).   Treatments : intra-aortocaval ... parathyroid hormone levels, baseline gastrin and insulin, chemotherapy. Related Conditions:  ...

IgG Multiple Myeloma

last regimen. In addition more conventional combination chemotherapy can be used (e.g. VAD). What are the next steps when ... intensity conditioning (RIC) regimens use less intensive chemotherapy or irradiation prior to the infusion of donor stem cells. This ...

Degenerative eye problems - Bilateral colloid degeneration

for Adenocarcinoma of the colon with subsequent chemotherapy and radiotherapy; -        ...

Cystic Pleuro-Pulmonary Blastoma – additional opinion

of distant metastasis. The initial plan is to proceed with chemotherapy using 3 cycles of VAIA followed by restaging and aggressive ... the parents, it was decided to start with 3 cycles of chemotherapy as per the protocol (VAIA) and afterwards to carry out a CT scan ...

Prostatic Adenocarcinoma

Estracyt and LHRH agonist. It is recommended to consider Chemotherapy as an another treatment option.   ...

Stage 4 Neuroblastoma – additional opinion

After the diagnosis of Stage 4 Neuroblastoma, he began chemotherapy treatment according to NB-AR-O1/ESIOP protocol, that has been, on ... protocol , that schedules a first phase of induction chemotherapy according to the COJEC scheme (8 cycles of chemotherapy) of the ...

Stage IV Melanoma

splenectomy, and resection of two subcutaneous lesions. Chemotherapy is also planned. ... region. Restaging is scheduled in March;  chemotherapy  planned for 03/2009 with CVD regimen (Cisplatin 30 mg/mq gg ... -        chemotherapy as a single agent  or combination -chemotherapy. This ...

Small Cell Neuroendocrine Tumor of the Cervix – additional opinion

were explained, as were treatment options (surgery, chemotherapy, radiation), including options to preserve fertility. ... aggressive but responsive to platinum-based combination chemotherapy . A review of cytotoxic chemotherapy for patients with high-grade ...

Secondary Malignancy in mesentery following primary rectal cancer with multiple colonic polyps

  A month following surgery the patient began chemotherapy with 5-FU 600 mg/sq m with leucovorin 500 mg/sq m once weekly ... Cr 1.8-2.0. Following cessation of the chemotherapy it took several weeks for his condition to stabilize. The ...

MDS – Myelodysplastic Syndrome

currently not being treated for my disease. I was offered chemotherapy, but I declined this treatment because of fear that it would ... into acute leukemia . The use of this relatively mild chemotherapy is associated with improve outcomes as described in Fenaux P, et ...

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