Clomifene or clomiphene or Clomid or Clomifert is a selective estrogen receptor modulator (SERM) that increases production of gonadotropins by inhibiting negative feedback on the hypothalamus. It is used mainly in female infertility, in turn mainly as ovarian stimulation to reverse oligoovulation or anovulation such as in infertility in polycystic ovary syndrome, as well as being used for ovarian hyperstimulation, such as part of an in vitro fertilization procedure. Clomifene citrate is marketed under various trade names including Clomid, Serophene, and Milophene.