Autologous Matrix-Induced Chondrogenesis (AMIC) is a biological treatment option which repairs articular cartilage damage. It combines microfracture surgery with the application of a bi-layer collagen I/III membrane. AMIC achieves pain relief and restores functionality in the joint with the goal to regain full mobility, allowing going back to previous lifestyle and activity level. It slows down cartilage degeneration with the intent to avoid or delay partial or total joint replacement surgery.