DOCTORS'
Medical Case Studies
DOCTORS'
Medical Case Studies
EGFR mutation
Epidermal growth factor receptor
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer. Epidermal Growth Factor was discovered by Stanley Cohen of Vanderbilt University along with Rita Levi-Montalcini for which both received the Nobel prize in Physiology or Medicine in 1986.
EGFR mutation - List of case studies
- Non Small Cell Lung cancer, Stage 4, S/P Right Pneumonectomy
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in having his tumor tissue sent for assessment of EGFR and KRAS mutations , as well as for the EML4-alk translocation ... that this "heavy smoker" will harbor an EGFR mutation or EML4-alk translocation, it is possible. Moreover, the presence of ...
- Multirelapse Squamed Carcinoma of the Skin
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inhibitors of the epidermal growth factor receptor (EGFR) may have an impact. We evaluated gefitinib as an induction therapy in a ... feasibility. Correlative studies of EGFR expression, gene mutation, and ploidy may serve as predictors of response. Methods: Eligible pts ...
- Metastatic non small cell lung Cancer
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option. If tissue available would be checked for EGFR mutation - if positive and if disease truly metastatic- Erlotinib . ...
- List of Examinations
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Chromosomal mapping of the family for the factor II mutation Chronic axon loss neuropathy Chronic neurogenic changes ... EBV-IgM levels ECG EEG EF evaluation EGFR mutation EKG EMG EMG (Electromyography - muscles of the ...
- Metastatic, Non Small Cell Lung Cancer
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effective option. If tissue available would check for EGFR mutation- if + and if disease truly metastatic- Erlotinib . ...