DOCTORS'
Medical Case Studies
DOCTORS'
Medical Case Studies
EGFR mutations
Epidermal growth factor receptor
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer. Epidermal Growth Factor was discovered by Stanley Cohen of Vanderbilt University along with Rita Levi-Montalcini for which both received the Nobel prize in Physiology or Medicine in 1986.
EGFR mutations - List of case studies
- Metastatic, Non Small Cell Lung Cancer – further opinion
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still think Erlotinib is a viable option especially if EGFR mutations are present. tags: ...
- Non Small Cell Lung cancer, Stage 4, S/P Right Pneumonectomy
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in having his tumor tissue sent for assessment of EGFR and KRAS mutations , as well as for the EML4-alk translocation . A number for ...