DOCTORS'
Medical Case Studies
DOCTORS'
Medical Case Studies
Megaloblastic anemia
Megaloblastic anemia
Megaloblastic anemia (or megaloblastic anaemia) is an anemia that results from inhibition of DNA synthesis in red blood cell production. When DNA synthesis is impaired, the cell cycle cannot progress from the G2 growth stage to the mitosis (M) stage. This leads to continuing cell growth without division, which presents as macrocytosis. The defect in red cell DNA synthesis is most often due to hypovitaminosis, specifically a deficiency of vitamin B and/or folic acid. Vitamin B deficiency alone will not cause the syndrome in the presence of sufficient folate, for the mechanism is loss of B dependent folate recycling, followed by folate-deficiency loss of nucleic acid synthesis (specifically thymine), leading to defects in DNA synthesis...
Megaloblastic anemia - List of case studies
- PANCYTOPENIA OF UNKNOWN ETIOLOGY
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bone marrow diseases such as aplastic / hypoplastic anemia , PNH , myeloproliferative disease and others. BM analysis and specific tests can help. - Megaloblastic anemia – B12 and / or folic acid deficiency. ...
- Symptomatic Pancytopenia
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pancytopenia. The main problem has been the symptomatic anemia, which required blood transfusions. Bone marrow aspiration revealed some ... and specific tests can help. Megaloblastic anemia – B12 and / or folic acid deficiency ...
- Pancytopenia of uncertain pathogenesis
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bone marrow diseases such as aplastic / hypoplastic anemia, PNH, myeloproliferative disease and others. BM analysis and specific tests can help. Megaloblastic anemia – B12 and / or folic acid deficiency ...