AIDS dementia complex (ADC; also known as HIV dementia, HIV encephalopathy, HIV-associated dementia and HIV-associated neurocognitive disorder) is a common neurological disorder associated with HIV infection and AIDS. It is a metabolic encephalopathy induced by HIV infection and fueled by immune activation of brain macrophages and microglia. These cells are actively infected with HIV and secrete neurotoxins of both host and viral origin. The essential features of ADC are disabling cognitive impairment accompanied by motor dysfunction, speech problems and behavioral change...