54-year-old obese male with end stage renal disease due to membranous nephropathy, has received 2 renal transplants in the past and is highly sensitized. He underwent coronary angiography for vessel CAD, and PTCAs and stanting were performed. His current treatment consists of multiple medications including mycophylate according to the instructions of his transplant nephrologist. His cardiologists sees no contraindication to transplantation.

The expert answers various questions referred to him regarding ABO-incompatible (ABOI) renal transplantation without splenectomy, using antigen-specific immunoadsorption (IA) and rituximab.